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- Title
GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.
- Authors
Ittiwut, Chupong; Yang, Bao-Zhu; Kranzler, Henry R; Anton, Raymond F; Hirunsatit, Rungnapa; Weiss, Roger D; Covault, Jonathan; Farrer, Lindsay A; Gelernter, Joel
- Abstract
GABRG1 and GABRA2, genes that encode the γ1 and α2 subunits, respectively, of the GABA-A receptor, are located in a cluster on chromosome 4p. Association of alcohol dependence (AD) with markers located at the 3' region of GABRA2 has been replicated in several studies, but recent studies suggested the possibility that the signal may be attributable to the adjacent gene, GABRG1, located 90 kb distant in the 3' direction. Owing to strong linkage disequilibrium (LD) in European Americans (EAs), the origin, or origins, of the association signal is very difficult to discern, but our previous population-based study suggested that decreased LD across the GABRG1-GABRA2 region in African Americans (AAs) may be useful for fine mapping and resolution of the association signal in that population.
- Publication
Alcoholism, clinical and experimental research, 2012, Vol 36, Issue 4, p588
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2011.01637.x