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- Title
Effects of withdrawal from chronic intermittent ethanol vapor on the level and circadian periodicity of running-wheel activity in C57BL/6J and C3H/HeJ mice.
- Authors
Logan, Ryan W; McCulley, Walter D, 3rd; Seggio, Joseph A; Rosenwasser, Alan M
- Abstract
Alcohol withdrawal is associated with behavioral and chronobiological disturbances that may persist during protracted abstinence. We previously reported that C57BL/6J (B6) mice show marked but temporary reductions in running-wheel activity, and normal free-running circadian rhythms, following a 4-day chronic intermittent ethanol (CIE) vapor exposure (16 hours of ethanol vapor exposure alternating with 8 hours of withdrawal). In the present experiments, we extend these observations in 2 ways: (i) by examining post-CIE locomotor activity in C3H/HeJ (C3H) mice, an inbred strain characterized by high sensitivity to ethanol withdrawal, and (ii) by directly comparing the responses of B6 and C3H mice to a longer-duration CIE protocol.
- Publication
Alcoholism, clinical and experimental research, 2012, Vol 36, Issue 3, p467
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2011.01634.x