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- Title
Ethanol alters BDNF-induced Rho GTPase activation in axonal growth cones.
- Authors
Lindsley, Tara A; Shah, Samit N; Ruggiero, Elizabeth A
- Abstract
The effects of ethanol on development of postmitotic neurons include altered neurite outgrowth and differentiation, which may contribute to neuropathology associated with fetal alcohol spectrum disorders. We previously reported that ethanol exposure alters axon growth dynamics in dissociated cultures of rat hippocampal pyramidal neurons. Given the important regulatory role of small Rho guanosine triphosphatases (GTPases) in cytoskeletal reorganization associated with axon growth, and reports that ethanol alters whole cell Rho GTPase activity in other cell types, this study explored the hypothesis that ethanol alters Rho GTPase activity specifically in axonal growth cones.
- Publication
Alcoholism, clinical and experimental research, 2011, Vol 35, Issue 7, p1321
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2011.01468.x