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- Title
Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages.
- Authors
Jin, Mengyao; Arya, Priyanka; Patel, Kalpeshkumar; Singh, Bhupendra; Silverstein, Peter S; Bhat, Hari K; Kumar, Anil; Kumar, Santosh
- Abstract
ATP-binding cassette (ABC) proteins and cytochrome P450 (CYP) enzymes regulate the bioavailability of HIV-1 antiretroviral therapeutic drugs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). They are also involved in regulating, and responding to, oxidative stress in various tissues and organs including liver. This study is designed to assess the effect of alcohol on the ABCC1 and CYP enzymes involved in the metabolism of NNRTIs and PIs (CYP2B6, CYP2D6, and CYP3A4) and oxidative stress (CYP1A1, CYP2A6, and CYP2E1) in U937 macrophages. The U937 cell line has been utilized as an in vitro model of human macrophages.
- Publication
Alcoholism, clinical and experimental research, 2011, Vol 35, Issue 1, p132
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2010.01330.x