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- Title
Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.
- Authors
Matsumoto, Michinaga; Cyganek, Izabela; Sanghani, Paresh C; Cho, Won Kyoo; Liangpunsakul, Suthat; Crabb, David W
- Abstract
Human class I alcohol dehydrogenase 2 isoenzymes (encoded by the ADH1B locus) have large differences in kinetic properties; however, individuals inheriting the alleles for the different isoenzymes exhibit only small differences in alcohol elimination rates. This suggests that other cellular factors must regulate the activity of the isoenzymes.
- Publication
Alcoholism, clinical and experimental research, 2011, Vol 35, Issue 1, p28
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2010.01319.x