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- Title
Implications of ER stress, the unfolded protein response, and pro- and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol.
- Authors
Boukli, Nawal M; Saiyed, Zainulabedin M; Ricaurte, Martha; Rodriguez, José W; Ríos Olivares, Eddy; Cubano, Luis A; Nair, Madhavan P N
- Abstract
Dendritic cells (DCs) are responsible for the activation of T cells and B cells. There is accumulating evidence that psychoactive substances such as alcohol can affect immune responses. We hypothesize that this occurs by modulating changes in proteins triggering a process known as unfolded protein response (UPR). This process protects cells from the toxic effects of misfolded proteins responsible for causing endoplasmic reticulum (ER) stress. Although much is known about ER stress, little is understood about the consequences of ethanol use on DC's protein expression.
- Publication
Alcoholism, clinical and experimental research, 2010, Vol 34, Issue 12, p2081
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2010.01304.x