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- Title
Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial.
- Authors
Garbutt, James C; Kampov-Polevoy, Alexei B; Gallop, Robert; Kalka-Juhl, Linda; Flannery, Barbara A
- Abstract
Recent clinical trials and case-reports indicate that baclofen, a GABA(B) agonist, may have efficacy for alcohol dependence. Baclofen has been shown to enhance abstinence, to reduce drinking quantity, to reduce craving, and to reduce anxiety in alcohol-dependent individuals in 2 placebo-controlled trials in Italy. However, the clinical trial data with baclofen is limited. The purpose of the present study was to test the efficacy and tolerability of baclofen in alcohol dependence in the United States.
- Publication
Alcoholism, clinical and experimental research, 2010, Vol 34, Issue 11, p1849
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2010.01273.x