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- Title
Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7.
- Authors
Godin, Elizabeth A; O'Leary-Moore, Shonagh K; Khan, Amber A; Parnell, Scott E; Ament, Jacob J; Dehart, Deborah B; Johnson, Brice W; Allan Johnson, G; Styner, Martin A; Sulik, Kathleen K
- Abstract
This magnetic resonance microscopy (MRM)-based report is the second in a series designed to illustrate the spectrum of craniofacial and central nervous system (CNS) dysmorphia resulting from single- and multiple-day maternal ethanol treatment. The study described in this report examined the consequences of ethanol exposure on gestational day (GD) 7 in mice, a time in development when gastrulation and neural plate development begins; corresponding to the mid- to late third week postfertilization in humans. Acute GD 7 ethanol exposure in mice has previously been shown to result in CNS defects consistent with holoprosencephaly (HPE) and craniofacial anomalies typical of those in Fetal Alcohol Syndrome (FAS). MRM has facilitated further definition of the range of GD 7 ethanol-induced defects.
- Publication
Alcoholism, clinical and experimental research, 2010, Vol 34, Issue 1, p98
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2009.01071.x