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- Title
Alcohol up-regulates TLR2 through a NO/cGMP dependent pathway.
- Authors
Bailey, Kristina L; Sisson, Joseph H; Romberger, Debra J; Robinson, James E; Wyatt, Todd A
- Abstract
Heavy alcohol consumption is associated with severe bronchitis. This is likely related to increased inflammation in the airways of alcohol abusers. Toll-like receptor 2 (TLR2) is an important mediator of inflammation in the airway epithelium. TLR2 initiates an inflammatory cascade in response to gram-positive bacteria. We have previously shown that alcohol up-regulates TLR2 in the airway epithelium. However, the mechanism of alcohol-mediated up-regulation of TLR2 has not been identified.
- Publication
Alcoholism, clinical and experimental research, 2010, Vol 34, Issue 1, p51
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2009.01065.x