We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor.
- Authors
Arolfo, Maria P; Overstreet, David H; Yao, Lina; Fan, Peidong; Lawrence, Andrew J; Tao, Guoxin; Keung, Wing-Ming; Vallee, Bert L; Olive, M Foster; Gass, Justin T; Rubin, Emanuel; Anni, Helen; Hodge, Clyde W; Besheer, Joyce; Zablocki, Jeff; Leung, Kwan; Blackburn, Brent K; Lange, Louis G; Diamond, Ivan
- Abstract
Inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used for 1,000 years in traditional Chinese medicine to treat alcoholism. Kudzu contains daidzin, which inhibits ALDH-2 and suppresses heavy drinking in rodents. Decreased drinking due to ALDH-2 inhibition is attributed to aversive properties of acetaldehyde accumulated during alcohol consumption. However, daidzin can reduce drinking in some rodents without necessarily increasing acetaldehyde. Therefore, a selective ALDH-2 inhibitor might affect other metabolic factors involved in regulating drinking.
- Publication
Alcoholism, clinical and experimental research, 2009, Vol 33, Issue 11, p1935
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2009.01031.x