We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preclinical evaluation of riluzole: assessments of ethanol self-administration and ethanol withdrawal symptoms.
- Authors
Besheer, Joyce; Lepoutre, Veronique; Hodge, Clyde W
- Abstract
Many of the neurobehavioral effects of ethanol are mediated by inhibition of excitatory N-methyl-D-aspartate (NMDA) and enhancement of inhibitory gamma-amino-butyric-acid (GABA) receptor systems. There is growing interest in drugs that alter these systems as potential medications for problems associated with alcoholism. The drug riluzole, approved for treatment of amyotrophic lateral sclerosis (ALS), inhibits NMDA and enhances GABA(A) receptor system activity. This study was designed to determine the preclinical efficacy of riluzole to modulate ethanol self-administration and withdrawal.
- Publication
Alcoholism, clinical and experimental research, 2009, Vol 33, Issue 8, p1460
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2009.00976.x