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- Title
Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells.
- Authors
Allen-Gipson, Diane S; Jarrell, Justin C; Bailey, Kristina L; Robinson, James E; Kharbanda, Kusum K; Sisson, Joseph H; Wyatt, Todd A
- Abstract
Adenosine uptake into cells by nucleoside transporters plays a significant role in governing extracellular adenosine concentration. Extracellular adenosine is an important signaling molecule that modulates many cellular functions via 4 G-protein-coupled receptor subtypes (A(1), A(2A), A(2B), and A(3)). Previously, we demonstrated that adenosine is critical in maintaining airway homeostasis and airway repair and that airway host defenses are impaired by alcohol. Taken together, we hypothesized that ethanol impairs adenosine uptake via the nucleoside transport system.
- Publication
Alcoholism, clinical and experimental research, 2009, Vol 33, Issue 5, p791
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2009.00897.x