We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists.
- Authors
Scibelli, Angela C; Phillips, Tamara J
- Abstract
Muscarinic acetylcholine receptors (mAChRs) are well positioned to mediate ethanol's stimulant effects. To investigate this possibility, we examined the effects of scopolamine, a receptor subtype nonselective mAChR antagonist, on ethanol-induced stimulation in genotypes highly sensitive to this effect of ethanol. We also investigated whether the dopamine D1-like receptor antagonist, SCH-23390 or the dopamine D2-like receptor antagonist, haloperidol, could block the extreme stimulant response found following co-administration of scopolamine and ethanol.
- Publication
Alcoholism, clinical and experimental research, 2009, Vol 33, Issue 3, p435
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2008.00854.x