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- Title
The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling.
- Authors
Sparta, Dennis R; Ferraro, Frank M, 3rd; Fee, Jon R; Knapp, Darin J; Breese, George R; Thiele, Todd E
- Abstract
The alcohol deprivation effect (ADE) is characterized by transient excessive alcohol consumption upon reinstatement of ethanol following a period of ethanol deprivation. While this phenomenon has been observed in rats using both bottle drinking (consummatory behavior) and operant self-administration (consummatory and appetitive "ethanol-seeking" behavior) procedures, ADE studies in mice have primarily relied on bottle drinking measures. Furthermore, the neurochemical pathways that modulate the ADE are not well understood. Therefore, we determined whether the ADE can be observed in C57BL/6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor.
- Publication
Alcoholism, clinical and experimental research, 2009, Vol 33, Issue 1, p31
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2008.00808.x