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- Title
Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley rats.
- Authors
Navarro, Montserrat; Cubero, Inmaculada; Knapp, Darin J; Breese, George R; Thiele, Todd E
- Abstract
The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin (POMC). Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake. Because ethanol decreases POMC mRNA levels, we determined if exposure to an ethanol-containing diet (ED) would significantly reduce central immunoreactivity of the MC peptide alpha-MSH in rats. We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist.
- Publication
Alcoholism, clinical and experimental research, 2008, Vol 32, Issue 2, p266
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2007.00578.x