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- Title
Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes.
- Authors
Reilly, Matthew T; Lobo, Ingrid A; McCracken, Lindsay M; Borghese, Cecilia M; Gong, Diane; Horishita, Takafumi; Harris, R Adron
- Abstract
Acamprosate (calcium acetylhomotaurinate) has proven to be a moderately effective pharmacological adjunct for the treatment of alcoholism. However, the central nervous system mechanism by which acamprosate reduces alcohol relapse remains unclear. Here we survey a number of metabotropic receptors, ligand-gated ion channels, and voltage-gated ion channels, to determine if acamprosate has actions at these sites in the central nervous system.
- Publication
Alcoholism, clinical and experimental research, 2008, Vol 32, Issue 2, p188
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2007.00569.x