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- Title
Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: ovine model.
- Authors
Ramadoss, Jayanth; Lunde, Emilie R; Chen, Wei-Jung A; West, James R; Cudd, Timothy A
- Abstract
Human magnetic resonance imaging (MRI) and autopsy studies reveal abnormal cerebellar development in children who had been exposed to alcohol prenatally, independent of the exposure period. Animal studies conducted utilizing the rat model similarly demonstrate a broad period of vulnerability, albeit the third trimester-equivalent of human brain development is reported to be the most vulnerable period, and the first trimester-equivalent exposure produces cerebellar Purkinje cell loss only at high doses of alcohol. However, in the rat model, all 3 trimester-equivalents do not occur prenatally, requiring the assumption that intrauterine environment, placenta, maternal interactions, and parturition do not play an important role in mediating the damage. In this study, we utilized the ovine model, where all 3 trimester-equivalents occur in utero, to determine the critical window of vulnerability of fetal cerebellar Purkinje cells.
- Publication
Alcoholism, clinical and experimental research, 2007, Vol 31, Issue 10, p1738
- ISSN
0145-6008
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2007.00477.x