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- Title
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
- Authors
Wang, Jen C; Hinrichs, Anthony L; Bertelsen, Sarah; Stock, Heather; Budde, John P; Dick, Danielle M; Bucholz, Kathleen K; Rice, John; Saccone, Nancy; Edenberg, Howard J; Hesselbrock, Victor; Kuperman, Samuel; Schuckit, Marc A; Bierut, Laura J; Goate, Alison M
- Abstract
A novel family of G protein-coupled receptors, TAS2Rs, has recently been characterized and linked to sensitivity to bitter taste compounds. We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence. Other family-based studies on the genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). Haplotypes resulting from 3 common nonsynonymous coding single-nucleotide polymorphisms in the TAS2R38 gene have been shown to alter receptor functions and taste sensitivity to PTC and PROP. The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors.
- Publication
Alcoholism, clinical and experimental research, 2007, Vol 31, Issue 2, p209
- ISSN
0145-6008
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2006.00297.x