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- Title
Serum intercellular adhesion molecule-1 in patients with nonalcoholic steatohepatitis: comparison with alcoholic hepatitis.
- Authors
Ito, Shuji; Yukawa, Toyokazu; Uetake, Shinichiro; Yamauchi, Masayoshi
- Abstract
Nonalcoholic fatty liver disease (NAFLD) includes both nonalcoholic fatty liver (FL) and nonalcoholic steatohepatitis (NASH). It has previously been reported that alcoholic hepatitis, which shows morphological findings similar to that of NASH, leads to the onset of endotoxinemia and to an increase in the production of tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-1 (IL-1) from macrophages. Tumor necrosis factor-alpha and IL-1 induce strong expression of intercellular adhesion molecule-1 (ICAM-1) of the cell membranes of hepatocytes and/or sinusoidal endothelial cells, resulting in increased serum ICAM-1 levels in our previous study. In this study, we clarified the significance of serum ICAM-1 levels in patients with NAFLD, and especially in NASH.
- Publication
Alcoholism, clinical and experimental research, 2007, Vol 31, Issue 1 Suppl, pS83
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2006.00292.x