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- Title
Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice.
- Authors
Bessaïh, Thomas; de Yebenes, Esther Garcia; Kirkland, Kyle; Higley, Michael J; Buono, Russell J; Ferraro, Thomas N; Contreras, Diego
- Abstract
Most common forms of human epilepsy result from a complex combination of polygenetic and environmental factors. Quantitative trait locus (QTL) mapping is a first step toward the nonbiased discovery of epilepsy-related candidate genes. QTL studies of susceptibility to induced seizures in mouse strains have consistently converged on a distal region of chromosome 1 as a major phenotypic determinant; however, its influence on spontaneous epilepsy remains unclear. In the present study we characterized the influence of allelic variations within this QTL, termed Szs1, on the occurrence of spontaneous spike-wave discharges (SWDs) characteristic of absence seizures in DBA/2 (D2) mice.
- Publication
Epilepsia, 2012, Vol 53, Issue 8, p1429
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2012.03512.x