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- Title
L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue.
- Authors
Simeone, Kristina A; Sabesan, Shivkumar; Kim, Do Young; Kerrigan, John F; Rho, Jong M; Simeone, Timothy A
- Abstract
Human hypothalamic hamartomas (HHs) are associated with gelastic seizures, intrinsically epileptogenic, and notoriously refractory to medical therapy. We previously reported that the L-type calcium channel antagonist nifedipine blocks spontaneous firing and γ-aminobutyric acid (GABA)(A)-induced depolarization of single cells in HH tissue slices. In this study, we examined whether blocking L-type calcium channels attenuates emergent activity of HH neuronal networks.
- Publication
Epilepsia, 2011, Vol 52, Issue 3, p531
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2010.02942.x