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- Title
Evaluation of depression risk in LGI1 mutation carriers.
- Authors
Heiman, Gary A; Kamberakis, Kay; Gill, Richard; Kalachikov, Sergey; Pedley, Timothy A; Hauser, W Allen; Ottman, Ruth
- Abstract
Depression is the most common comorbid condition in epilepsy. The cause of this comorbidity is unknown, and could involve psychosocial consequences of epilepsy, treatment side effects, seizure manifestations, or common neurobiologic mechanisms. One hypothesis of particular interest is a shared genetic susceptibility to epilepsy and depression. We tested this hypothesis by studying depressive symptoms in families with an identified genetic form of epilepsy: autosomal dominant partial epilepsy with auditory features caused by mutations in the leucine-rich, glioma inactivated 1 gene (LGI1).
- Publication
Epilepsia, 2010, Vol 51, Issue 9, p1685
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2010.02677.x