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- Title
Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow.
- Authors
Ghosh, Chaitali; Gonzalez-Martinez, Jorge; Hossain, Mohammed; Cucullo, Luca; Fazio, Vincent; Janigro, Damir; Marchi, Nicola
- Abstract
P450 enzymes (CYPs) play a major role in hepatic drug metabolism. It is unclear whether these enzymes are functionally expressed by the diseased human blood-brain barrier (BBB) and are involved in local drug metabolism or response. We have evaluated the cerebrovascular CYP expression and function, hypothesizing possible implication in drug-resistant epilepsy.
- Publication
Epilepsia, 2010, Vol 51, Issue 8, p1408
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2009.02428.x