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- Title
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
- Authors
Aujla, Paven K; Fetell, Michael R; Jensen, Frances E
- Abstract
To test the efficacy of the novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model of hypoxic neonatal seizures. Talampanel is a noncompetitive antagonist of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid subtype of the glutamate receptor (AMPAR). We have previously shown that AMPARs play a critical role in the generation of acute seizures and later-life seizure susceptibility in this model of neonatal seizures.
- Publication
Epilepsia, 2009, Vol 50, Issue 4, p694
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2008.01947.x