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- Title
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
- Authors
Blanco, Miriam Marcela; dos Santos, Jair Guilherme, Jr; Perez-Mendes, Patrícia; Kohek, Silvia R B; Cavarsan, Clarissa Fantin; Hummel, Michele; Albuquerque, Cristovão; Mello, Luiz E
- Abstract
Pentylenetetrazole (PTZ) and maximal electroshock (MES) models are often used to induce seizures in nonepileptic control animals or naive animals. Despite being widely used to screen antiepileptic drugs (AEDs), both models have so far failed to detect potentially useful AEDs for treating drug-resistant epilepsies. Here we investigated whether the acute induction of MES and PTZ seizures in epileptic rats might yield a distinct screening profile for AEDs.
- Publication
Epilepsia, 2009, Vol 50, Issue 4, p824
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2008.01797.x