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- Title
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
- Authors
Tuveri, Antonella; Paoletti, Anna Maria; Orrù, Marisa; Melis, Gian Benedetto B; Marotto, Maria Francesca; Zedda, Pierina; Marrosu, Francesco; Sogliano, Cristiana; Marra, Carla; Biggio, Giovanni; Concas, Alessandra
- Abstract
Seizure exacerbation in catamenial epilepsy (CE) is associated with the decrease in progesterone secretion and increase in estradiol secretion during the premenstrual period. Moreover, experimental evidence suggests that tetrahydrodeoxycorticosterone (THDOC), a positive modulator of the type A receptor for gamma-aminobutyric acid (GABA), and dehydroepiandrosterone sulfate (DHEAS), a negative modulator of this receptor, might play a crucial role in modulating seizure frequency during the menstrual cycle. Following these studies it seems of interest to investigate possible variations, among other hormonal parameters, of THDOC and DHEAS in CE patients.
- Publication
Epilepsia, 2008, Vol 49, Issue 7, p1221
- ISSN
1528-1167
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2008.01555.x