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- Title
Protective effect of topiramate on kainic acid–induced cell death in mice hippocampus.
- Authors
Hae Jeong Park; Hak Jae Kim; Hi Joon Park; Jehyun Ra; Long Tai Zheng; Sung Vin Yim; Joo-Ho Chung
- Abstract
The protective effect of topiramate (TPM) on seizure-induced neuronal injury is well known; however, its molecular basis has yet to be elucidated. We investigated the effect and signaling mediators of TPM on seizure-induced hippocampal cell death in kainic acid (KA)-treated ICR mice. KA-induced hippocampal cell death was identified by terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling. Immunoreactivity (IR) of p-Erk, p-Jnk, p-P38, and caspase-3, and caspase-3 activity were observed in the hippocampal region 3 h after KA (0.1 μg/5 μL, i.c.v.) administration, and/or TPM (100 mg/kg, i.p.) pretreatment. TPM attenuated seizure-induced neuronal cell death and reduced KA-induced p-Erk IR in the CA3 region of the hippocampus, but did not affect p-Jnk and p-P38. In addition, TPM reduced caspase-3 IR and activation by KA. KA-induced seizures were also suppressed by TPM pretreatment. TPM inhibits seizures, and decreases Erk phosphorylation and caspase-3 activation by KA, thereby contributing to protection from neuronal injury.
- Publication
Epilepsia (Series 4), 2008, Vol 49, Issue 1, p163
- ISSN
0013-9580
- Publication type
Academic Journal
- DOI
10.1111/j.1528-1167.2007.01308.x