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- Title
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
- Authors
Erbayat-Altay, Ebru; Zeng, Ling-Hui; Xu, Lin; Gutmann, David H; Wong, Michael
- Abstract
Patients with tuberous sclerosis complex (TSC) often have severe epilepsy that is intractable to available therapies. The development of novel treatments for epilepsy in TSC would benefit greatly from a suitable animal model, but most animal models of TSC to date have few reported neurological abnormalities, such as epilepsy. We previously described a novel model of TSC, due to conditional inactivation of the Tsc1 gene in glia (Tsc1(GFAP)CKO mice), in which mice develop epilepsy and premature death. Here, we characterize the natural history of the epilepsy in Tsc1(GFAP)CKO mice in more detail and report acute effects of treatment with standard antiepileptic drugs on seizures in these mice.
- Publication
Epilepsia, 2007, Vol 48, Issue 8, p1470
- ISSN
0013-9580
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2007.01110.x