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- Title
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
- Authors
Man, Celeste B L; Kwan, Patrick; Baum, Larry; Yu, Evelyn; Lau, K M; Cheng, Alice S H; Ng, Margaret H L
- Abstract
A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals.
- Publication
Epilepsia, 2007, Vol 48, Issue 5, p1015
- ISSN
0013-9580
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2007.01022.x