We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
- Authors
Cucullo, Luca; Hossain, Mohammed; Rapp, Ed; Manders, Toby; Marchi, Nicola; Janigro, Damir
- Abstract
A biotechnologic breakthrough for the study of drug permeability across the blood-brain barrier (BBB) would be the use of a reproducible in vitro model that recapitulates the functional, structural, and pathologic properties of the BBB in situ. We developed a humanized dynamic in vitro BBB model (DIV-BBB) based on cocultures of human microvascular endothelial cells (HBMECs) from "normal" and drug-resistant epileptic brain tissue with human brain astrocytes (HAs) from epilepsy patients or controls.
- Publication
Epilepsia, 2007, Vol 48, Issue 3, p505
- ISSN
0013-9580
- Publication type
Journal Article
- DOI
10.1111/j.1528-1167.2006.00960.x