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Title
Improved opioid analgesic effect following opioid dose reduction.
Authors
Vorobeychik, Yakov; Chen, Lucy; Bush, Mary Chasko; Mao, Jianren
Abstract
Traditionally, opioids have been the cornerstone of therapy for patients suffering from cancer pain, regardless of the potential to develop opioid tolerance. In chronic pain patients who experience worsening pain despite increasing doses of opioids, the clinical role of opioid-induced hyperalgesia is gaining more recognition.
Publication
Pain medicine (Malden, Mass.), 2008, Vol 9, Issue 6, p724