We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Spontaneous intracranial hypotension-hypovolemia associated with tacrolimus.
- Authors
Ahn, Andrew H; Berman, Brian D; Dillon, William P
- Abstract
There is little precedent for a medication-induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus (FK506). A literature review for potential causes of a tacrolimus-induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use.
- Publication
Headache, 2010, Vol 50, Issue 8, p1386
- ISSN
1526-4610
- Publication type
Journal Article
- DOI
10.1111/j.1526-4610.2010.01701.x