We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs).
- Authors
Saraswati, Sarika; Deskins, Desirae L; Holt, Ginger E; Young, Pampee P
- Abstract
We and others have found that Wnt signaling inhibition is important in mesenchymal stem cell (MSC) self-renewal. Pyrvinium was identified as a potent Wnt inhibitor in a chemical screen for small molecules. In the present study, we hypothesized that pyrvinium will enhance MSC self-renewal to improve the clinical efficacy of MSC therapy. Pyrvinium increased MSC proliferation in vitro while inhibiting their osteogenic and chondrogenic lineage commitment by reducing cytoplasmic β-catenin. Although MSCs are a promising target for cell therapy, strategies to enhance their survival and maintain their stemness in the wounded area are essential. Using an in vivo model of granulation tissue formation, we demonstrated that pyrvinium enhanced long-term MSC engraftment. Pyrvinium-treated MSC-generated granulation tissue also demonstrated less ectopic differentiation into bone or cartilage. This study highlights the potential of using a therapeutic Wnt inhibitor to enhance MSC-driven regenerative therapy.
- Publication
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2012, Vol 20, Issue 2, p185
- ISSN
1524-475X
- Publication type
Journal Article
- DOI
10.1111/j.1524-475X.2012.00767.x