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- Title
Hypoglycemic Coma Secondary to Big Insulin-like Growth Factor II Secretion by a Giant Phyllodes Tumor of the Breast.
- Authors
Bujanda, David Aguiar; Vera, José Carlos Rivero; Suárez, Miguel Ángel Cabrera; Morales, José Aguiar; Christol, Rémy; Sarmiento, Uriel Bohn; Cabrera, Casimira Domínguez; Bouc, Yves Le
- Abstract
Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
- Publication
Breast Journal, 2007, Vol 13, Issue 2, p189
- ISSN
1075-122X
- Publication type
Academic Journal
- DOI
10.1111/j.1524-4741.2007.00398.x