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- Title
A computer simulation model of the natural history and economic impact of chronic obstructive pulmonary disease.
- Authors
Borg, Sixten; Ericsson, Asa; Wedzicha, Jadwiga; Gulsvik, Amund; Lundbäck, Bo; Donaldson, Gavin C; Sullivan, Sean D
- Abstract
Chronic obstructive pulmonary disease (COPD) is a major health problem with high societal costs. The Global Initiative for Chronic Lung Disease (GOLD) has identified a need for health economics data for COPD. For chronic diseases, such as COPD, where the natural history of disease is lifetime, a modeling approach for economic evaluation may be more realistic than prospective, piggy-backed clinical trials or specific COPD cohort studies. Simulation models can be used to extrapolate clinical data beyond the limited time frame of clinical trials, to analyze subgroups of patients or to explore uncertainty regarding the results by using sensitivity analysis techniques. Our purpose has been to develop a flexible computer simulation model for COPD that will represent disease progression and GOLD recommendations, useful for economic evaluations of new medicines to meet the needs of various payer requirements for reimbursement and resource allocation.
- Publication
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2004, Vol 7, Issue 2, p153
- ISSN
1098-3015
- Publication type
Journal Article
- DOI
10.1111/j.1524-4733.2004.72318.x