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- Title
High Eradication Rates of Helicobacter pylori Infection Following Sequential Therapy: The Israeli Experience Treating Naïve Patients.
- Authors
Schmiloviz-Weiss, Hemda; Shalev, Tamar; Chechoulin, Yelena; Levi, Zohar; Yishai, Ron; Sehayek-Shabbat, Vered; Niv, Yaron; Shirin, Haim
- Abstract
Helicobacter pylori eradication rates following triple therapy are decreasing. Cure rates as low as 57%, mainly to claritromycin resistance, have been reported in Israel. Studies performed in Italy have shown eradication rates of 93%, following sequential therapy. Our aim was to evaluate the effect of sequential therapy on eradication rates of H. pylori in naïve Israeli patients. Consecutive patients referred for esophagogastroduodenoscopy with a positive rapid urease test and positive C urea breath test were included. Patients received omeprazole 20 mg bid and amoxicillin 1 g bid for 5 days followed by omeprazole 20 mg bid, clarithromycin 500 mg bid and tinidazole 500 mg bid for the subsequent 5 days. A second C urea breath test was performed at least 4 weeks after completion of therapy. Patients were asked to avoid antibiotics, bismuth compounds or proton pump inhibitor until after the second C urea breath test. Adverse effects were documented by a questionnaire. One hundred and twenty-four patients (mean age 56.1 ± 12.5 years, 55.6% women) were included; 120/124 (96.8%) completed treatment and performed the second C urea breath test. Two patients (1.6%) were lost to follow-up; 2 (1.6%) were noncompliant with study regulations. One hundred and fifteen patients achieved eradication of H. pylori. The eradication rate was 95.8% by per protocol analysis and 92.7% by intention to treat analysis. The sequential regimen attained significantly higher eradication rates in naïve patients than usually reported for conventional triple therapy. Sequential therapy may be an alternative first-line therapy in eradicating H. pylori in Israel.
- Publication
Helicobacter, 2011, Vol 16, Issue 3, p229
- ISSN
1083-4389
- Publication type
Academic Journal
- DOI
10.1111/j.1523-5378.2011.00834.x