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- Title
Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production.
- Authors
Molnár, Gergõ A; Wagner, Zoltán; Markó, Lajos; Kó Szegi, Tamás; Mohás, Márton; Kocsis, Béla; Matus, Zoltán; Wagner, László; Tamaskó, Mónika; Mazák, István; Laczy, Boglárka; Nagy, Judit; Wittmann, István
- Abstract
Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on the renal handling of the different tyrosine isomers and, furthermore, to measure urinary levels of 8-epi-prostaglandin-F(2alpha), a marker of lipid peroxidation.
- Publication
Kidney international, 2005, Vol 68, Issue 5, p2281
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2005.00687.x