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- Title
Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II.
- Authors
Deng, Aihua; Miracle, Cynthia M; Suarez, Jorge M; Lortie, Mark; Satriano, Joseph; Thomson, Scott C; Munger, Karen A; Blantz, Roland C
- Abstract
Oxygen mitochondrial effects consumption by the kidney (Qo(2)), is linearly related to sodium reabsorption (T(na)), but recent studies suggest this relationship is variable and that metabolic efficiency (Qo(2)/T(na)) in kidney is regulated by hormonal factors. In the dog, nonselective inhibitors of nitric oxide synthase (NOS) increase Qo(2) and Qo(2)/T(na). Glomerular hemodynamic and reabsorptive consequences of NOS inhibition require angiotensin II (Ang II), implying an antagonistic relationship between nitric oxide and Ang II. Effects of NOS inhibition in the rat, the role of Ang II and the responsible NOS isoform have not been elucidated.
- Publication
Kidney international, 2005, Vol 68, Issue 2, p723
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2005.00450.x