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- Title
The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice.
- Authors
Ivanovski, Ognen; Szumilak, Dorota; Nguyen-Khoa, Thao; Ruellan, Nadya; Phan, Olivier; Lacour, Bernard; Descamps-Latscha, Béatrice; Drüeke, Tilman B; Massy, Ziad A
- Abstract
Cardiovascular disease is the most frequent cause of mortality in chronic renal failure (CRF). Therefore, it is important to identify appropriate treatment measures. The antioxidant N-acetylcysteine (NAC) has been shown to reduce cardiovascular events in hemodialysis patients. Here we examine a possible direct effect of NAC supplementation on uremia-enhanced atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice.
- Publication
Kidney international, 2005, Vol 67, Issue 6, p2288
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2005.00332.x