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- Title
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants.
- Authors
Pat, Betty; Yang, Tao; Kong, Chuize; Watters, Dianne; Johnson, David W; Gobe, Glenda
- Abstract
A recent in vitro model of oxidative stress-induced renal fibrosis demonstrated that activated or phosphorylated extracellular signal-regulated protein kinase (pERK) played a role in apoptosis of renal fibroblasts, but not tubular epithelium where it promoted cell growth and survival. The present study utilized an in vivo model of renal fibrosis after unilateral ureteral obstruction (UUO) to examine the relationship between pERK, apoptosis, proliferation, and differentiation in renal fibroblast and tubular epithelial cells, in comparison with the in vitro results.
- Publication
Kidney international, 2005, Vol 67, Issue 3, p931
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2005.00157.x