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- Title
Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel.
- Authors
Masaki, Takahisa; Rathi, Ramesh; Zentner, Gaylen; Leypoldt, John K; Mohammad, Syed F; Burns, Gregory L; Li, Li; Zhuplatov, Sergey; Chirananthavat, Thanit; Kim, Seung-Jung; Kern, Steven; Holman, John; Kim, Sung Wan; Cheung, Alfred K
- Abstract
Neointimal hyperplasia occurs commonly at the anastomoses of arteriovenous grafts for chronic hemodialysis, causing stenosis and occlusion. Antiproliferative drugs may be effective in inhibiting hyperplasia, but local drug delivery would be required to minimize systemic side effects. We examined the feasibility of local drug delivery to inhibit neointimal hyperplasia at dialysis grafts in a canine model.
- Publication
Kidney international, 2004, Vol 66, Issue 5, p2061
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2004.00985.x