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- Title
Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells.
- Authors
Yi, Fan; Zhang, Andrew Y; Janscha, Jennifer L; Li, Pin-Lan; Zou, Ai-Ping
- Abstract
We recently demonstrated that homocysteine (Hcys) increases superoxide (O2-) production via NADH/NADPH oxidase in renal mesangial cells. This O2- production contributes to increased expression of tissue inhibitor of metalloproteinase (TIMP-1) and consequent deposition of collagen in response to Hcys. However, the mechanism by which Hcys activates NADH/NADPH oxidase remains unknown. Given that ceramide is an intracellular activator of this oxidase in several cell types, the present study tests the hypothesis that Hcys activates NADH/NADPH oxidase through a ceramide-mediated signaling pathway in rat mesangial (MG) cells, resulting in O2- production.
- Publication
Kidney international, 2004, Vol 66, Issue 5, p1977
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2004.00968.x