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- Title
TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells.
- Authors
Nee, Larine E; McMorrow, Tara; Campbell, Eric; Slattery, Craig; Ryan, Michael P
- Abstract
Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) may be an important mechanism in this process. The presence of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and their effects on proximal tubular cells may be critical in this process.
- Publication
Kidney international, 2004, Vol 66, Issue 4, p1376
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2004.00900.x