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- Title
Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress.
- Authors
Zhang, Jenny J; Bledsoe, Grant; Kato, Kazuo; Chao, Lee; Chao, Julie
- Abstract
High salt intake induces hypertension, cardiac hypertrophy, and progressive renal damage. Progressive renal injury is the consequence of a process of destructive fibrosis. Using gene transfer approach, we have shown that the tissue kallikrein-kinin system (KKS) plays an important role in protection against renal injury in several hypertensive rat models. In this study, we further investigated the effect and potential mechanisms mediated by kallikrein on salt-induced renal fibrosis.
- Publication
Kidney international, 2004, Vol 66, Issue 2, p722
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2004.00794.x