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- Title
Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.
- Authors
Inazaki, Kumi; Kanamaru, Yutaka; Kojima, Yuko; Sueyoshi, Noriyoshi; Okumura, Ko; Kaneko, Kazunari; Yamashiro, Yuichiro; Ogawa, Hideoki; Nakao, Atsuhito
- Abstract
Transforming growth factor-beta (TGF-beta) has been implicated in the development of renal fibrosis induced by unilateral ureteral obstruction (UUO). However, there is little information on signaling pathways mediating TGF-beta activity involved in molecular and cellular events leading to renal fibrosis induced by UUO. In this study, we sought to determine whether Smad3, a major signaling component of TGF-beta, mediated renal fibrosis induced by UUO.
- Publication
Kidney international, 2004, Vol 66, Issue 2, p597
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1111/j.1523-1755.2004.00779.x