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- Title
Effect of cocaine use on methadone pharmacokinetics in humans.
- Authors
McCance-Katz, Elinore F; Jatlow, Peter; Rainey, Petrie M
- Abstract
Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in C(min) (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure.
- Publication
The American journal on addictions, 2010, Vol 19, Issue 1, p47
- ISSN
1521-0391
- Publication type
Journal Article
- DOI
10.1111/j.1521-0391.2009.00009.x