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- Title
Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma.
- Authors
Eurich, Dennis; Boas-Knoop, Sabine; Morawietz, Lars; Neuhaus, Ruth; Somasundaram, Rajan; Ruehl, Martin; Neumann, Ulf P; Neuhaus, Peter; Bahra, Marcus; Seehofer, Daniel
- Abstract
Development of end-stage liver and graft disease is suspected to be partially determined by the individual genetic background. Mannose-binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL-2 alter MBL functionality. The aim of our study was to determine the prevalence of MBL-2 polymorphism (rs7096206) in hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) based on histological analysis of explanted livers in patients undergoing liver transplantation (LT).
- Publication
Liver international : official journal of the International Association for the Study of the Liver, 2011, Vol 31, Issue 7, p1006
- ISSN
1478-3231
- Publication type
Journal Article
- DOI
10.1111/j.1478-3231.2011.02522.x