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- Title
A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade.
- Authors
Di Stefano, Giuseppina; Fiume, Luigi; Baglioni, Michele; Bolondi, Luigi; Busi, Corrado; Chieco, Pasquale; Kratz, Felix; Manaresi, Francesca; Pariali, Milena
- Abstract
Doxorubicin (DOXO) was coupled to lactosaminated human serum albumin (L-HSA) in order to enhance the drug concentration in the well differentiated hepatocellular carcinomas (HCCs), which can accumulate L-HSA through the asialoglycoprotein receptor. In the present experiments we compared the DOXO concentrations produced by this conjugate (L-HSA-DOXO) and by the uncoupled drug in the well, moderately, and poorly differentiated rat HCCs.
- Publication
Liver international : official journal of the International Association for the Study of the Liver, 2006, Vol 26, Issue 6, p726
- ISSN
1478-3223
- Publication type
Journal Article
- DOI
10.1111/j.1478-3231.2006.01289.x