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- Title
Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58.
- Authors
Zhang, F; Mi, Y; Qi, J L; Li, J W; Si, M; Guan, B C; Du, X N; An, H L; Zhang, H L
- Abstract
Modulation of K(v)7/M channel function represents a relatively new strategy to treat neuronal excitability disorders such as epilepsy and neuropathic pain. We designed and synthesized a novel series of pyrazolo[1,5-a] pyrimidin-7(4H)-one compounds, which activate K(v)7 channels. Here, we characterized the effects of the lead compound, QO-58, on K(v)7 channels and investigated its mechanism of action.
- Publication
British journal of pharmacology, 2013, Vol 168, Issue 4, p1030
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2012.02232.x