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- Title
3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway.
- Authors
Solesio, Maria E; Saez-Atienzar, Sara; Jordan, Joaquin; Galindo, Maria F
- Abstract
Huntington's disease is a neurodegenerative process associated with mitochondrial alterations. Inhibitors of the electron-transport channel complex II, such as 3-nitropropionic acid (3NP), are used to study the molecular and cellular pathways involved in this disease. We studied the effect of 3NP on mitochondrial morphology and its involvement in macrophagy.
- Publication
British journal of pharmacology, 2013, Vol 168, Issue 1, p63
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2012.01994.x